The American Society for Apheresis (ASFA) conducted a 1 day consensus conference on Thrombotic Thrombo-cytopenic Purpura (TTP) during its annual meeting in Atlanta, GA, on April 10, 2012. The authors of this arti-cle, a subcommittee of ASFA’s Clinical Applications Committee, developed several questions with regard todefinitions, classification, pathophysiology, diagnosis, management, and future research in TTP. These questionswere provided to the seven invited speakers who are the experts in the field of TTP. Two moderators conductedthe proceedings of the conference which was attended by more than 100 participants. After each presentation,there was an open discussion that included moderator-selected written questions submitted by the audience. Amedical writer-generated transcript of the proceedings as well as each presentation was made available to theauthors. Each summary was reviewed and approved by the respective speaker before submission of this article.The subcommittee also developed seven key questions for blinded, electronic polling conducted by the modera-tors to generate a consensus amongst the speakers. This article includes these presentation summaries as well asresults of the electronic poll.